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1月25日学术报告：Exploration on Imaging methods for crystalline matter using synchron and FEL X-ray sources

来源： 发布时间：2024-01-24【字体：大 中 小】

报告人：李楚峰 DESY自由电子激光科学中心

会议时间：2024年1月25日 上午10:00-11:30

会议地点： 清河路390号 溢智厅

报告内容：

The superior brightness and short pulse duration of X-ray free electron laser (XFEL) allows it to outrun radiation damage in coherent diffractive imaging. In each imaging event, the elastic scattering terminates before photoelectron cascades commences. This “diffract-before-destroy” feature of XFEL opened up new opportunities for molecular imaging and structure studies by breaking the dose limit to samples. In this talk, we introduce typical XFEL diffractive imaging experimental schemes, data collection modes including serial femtosecond crystallography (SFX), sample delivery and data analysis pipeline. The serial data collection nature using XFEL pulses requires huge data volume for structure determination and the data efficiency is relatively low for weakly diffracting protein samples. These challenges motivated both analysis algorithm, software development for big data, and exploration of new diffraction schemes. Here, we showcase Click-X, EZ-hitfinder as fast, user-friendly and open source on-line data reduction tools in Python environment. SPIND was developed as a general auto-indexer for sparse diffraction data to maximize the data utilization. Convergent beam X-ray diffraction scheme(CBD) was also explored using multi-layer Laue lenses. It was demonstrated that B12 structure can be determined to resolution of ~1A from 100 patterns due to the enhanced sampling power of CBD scheme. The unique CBD geometry establishes one-to-one mapping between the real and reciprocal space. This feature enables CBD microcopy and the 3-D diffraction efficiency map can be obtained in addition to molecular structure in one process. This multi-modality imaging scheme can be applied to studies in both material and life sciences.

报告人简介：

2008年毕业于武汉大学物理学专业，2010 年获得武汉大学凝聚态物理学硕士学位，2016年获得美国亚利桑那州立大学生物物理学博士学位。2016年至2019, 亚利桑那州立大学生物物理中心/美国国家科学基金(NSF) BioXFEL STC项目博士后研究员，主要从事序列飞秒晶体学数据分析算法研究与软件开发 ，以及生物大分子超快动力学双色衍射方法开发。现任德国电子同步加速器研究所科学家职位，于（DESY）自由电子激光科学中心，从事相干汇聚X光晶体学，衍射显微学方法开发。

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