Dual-Band Full-Range Fourier Domain Optical Coherence Tomography

题目：Dual-Band Full-Range Fourier Domain Optical Coherence Tomography

姓名：Prof. Ping Yu

单位：Department of Physics and Astronomy, University of Missouri

时间：2013年6月17号（周一）上午10:00

地点：溢智厅

报告摘要：

Optical coherence tomography using low coherence interferometer in the near infrared wavelength regime has shown great potential in biomedical imaging. OCT acquires interferograms of sample and reference, and reconstructs the interferograms into intensity images to show sample microstructures. As commonly known in optical microscopy, it is difficult to differentiate tissue types merely based on the intensity images. Dual-band OCT, which uses light sources covering two distinct wavelength bands, has been shown to be a simple and powerful functional extension of intensity images in OCT. Among various OCT techniques, dual–band full-range Fourier domain OCT (FD-OCT) takes advantage of high sensitivity, speed and interferometric stability of Fourier domain method, and shows many advantages over conventional OCT in coherence domain tissue imaging. However, previous dual-band FD-OCT has a limitation that could not correctly give the tissue spectroscopic contrast due to depth-related discrepancy and tissue attenuation. In this talk, I will review the dual-band FD-OCT techniques and discuss technical challenges in the complex interference. I will present a recent progress in my research group of using an algorithm to correct the depth related fall-off and the light attenuation in the tissue, and a new design of dual-band full-range FD-OCT imaging system using the algorithm. The newly developed dual-band full-range FD-OCT system has been used to study human cancer xenografts and muscle tissues dissected from severely compromised immune deficient mice. With the depth-related compensations, improved sensitivity and corrected tissue spectroscopic contrast were achieved.